ABSTRACT
<p><b>OBJECTIVE</b>To investigate the genetic association pattern between single-nucleotide polymorphisms (SNP) in the interleukin-1 receptor-associated kinase 4 (IRAK-4) gene and allergic rhinitis (AR).</p><p><b>METHODS</b>A population of 379 patients with the diagnosis of AR and 333 healthy controls who lived in Beijing region was recruited. A total of 8 reprehensive marker SNP which were in IRAK-4 gene region were selected according to the Beijing people database from Hapmap website. The individual genotyping was performed by MassARRAY platform. SPSS 13.0 software was used for statistic analysis.</p><p><b>RESULTS</b>Subgroup analysis for the presence of different allergen sensitivities displayed associations only in the house dust mite-allergic cohorts (rs3794262: P = 0.0034, OR = 1.7388; rs4251481: P = 0.0023, OR = 2.6593), but not in subjects who were allergic to pollens as well as mix allergens.</p><p><b>CONCLUSION</b>The potential genetic contribution of the IRAK-4 gene to AR demonstrated an allergen-dependant association pattern in Chinese population.</p>
Subject(s)
Adolescent , Adult , Aged , Child , Child, Preschool , Female , Humans , Male , Middle Aged , Young Adult , Allergens , Genetics , Allergy and Immunology , Asian People , Genetics , Case-Control Studies , Genetic Predisposition to Disease , Genotype , Interleukin-1 Receptor-Associated Kinases , Genetics , Allergy and Immunology , Polymorphism, Single Nucleotide , Rhinitis, Allergic, Perennial , Genetics , Allergy and Immunology , Rhinitis, Allergic, Seasonal , Genetics , Allergy and ImmunologyABSTRACT
<p><b>OBJECTIVE</b>To investigate whether the single nucleotide polymorphisms (SNP) in the FCER1A gene are associated with serum total IgE level in Chinese allergic rhinitis (AR) cohort.</p><p><b>METHODS</b>A total of 378 patients diagnosed as AR was included in this study. Serum total IgE level was detected by UniCAP100 testing system. A total of 8 representativeness marker SNP which were in FCER1A gene region were selected according to the Beijing people database from Hapmap website and the running results of Haploview 4.1 software. The individual genotyping was performed by MassARRAY platform.</p><p><b>RESULTS</b>Three hundred and seventy-eight individuals (227 males and 151 females) with AR were prospectively recruited. The median of the total serum IgE measurements for the study population were 150 kU/L and ranged from 6.94 kU/L to 5000 kU/L. Levene tests showed the homogeneity of variance of total IgE level among different genotypes regarding each SNP locus. ANOVA tests demonstrated that none of the selected polymorphism loci in FCER1A was associated with total IgE level.</p><p><b>CONCLUSION</b>Present study failed to find an association between SNP in the FCER1A gene region and serum total IgE level in Chinese AR.</p>